At international level, he features for San Marino U21. His main role on the pitch is Forward. His estimated market valuation currently stands at 50K €.

His latest transfer saw him join SP Domagnano from San Marino Academy U22 via on 2025-08-11.

During the San Marino Campionato di Calcio 2025-2026 campaign, Simone Santi made 18 appearances, scoring 2 goals and adding 0 assists. He averaged 0.1 goals per match from 0 shots, with 0 on target.