Guillermo De los Santos is a professional footballer from URU and is currently 36 years old. He is on the books of Defensor Sporting Montevideo and wears shirt number 3. His main role on the pitch is Defender. He measures 180cm in height and weighs 75kg. His stronger foot is Right. His estimated market valuation currently stands at 125K €.

His latest transfer saw him join Defensor Sporting Montevideo from Coritiba PR via on 2023-01-10.

Across the Uruguay Primera Division 2026, Guillermo De los Santos appeared in 3 matches and averaged 0 tackles, 0 interceptions, 0 clearances, and 0 blocked shots per game.